Start Updating the manifest mf

Updating the manifest mf

There are several different definitions of TIA in use with no single agreed-on definition.

The Stroke Council of the American Heart Association/American Stroke Association convened a writing group to develop an expert consensus document for an updated definition of stroke for the 21st century.

Central nervous system infarction is defined as brain, spinal cord, or retinal cell death attributable to ischemia, based on neuropathological, neuroimaging, and/or clinical evidence of permanent injury.

This document represents the final expert consensus, summarized in Table 1, which has been peer reviewed as well as reviewed by the endorsing/affirming organizations.

This document will be updated in the future as the science of the field advances.

The leadership of the AHA/ASA reached out to colleagues from the American Academy of Neurology, the American Association of Neurological Surgeons and Congress of Neurological Surgeons, the US Food and Drug Administration, the US Centers for Disease Control and Prevention, the National Institute of Neurological Disorders and Stroke, and others to establish a universal definition of stroke based on the current understanding of pathophysiology, as well as implications for clinical practice, research, and public policy.* The writing group was composed of experts in neurology, neurosurgery, neuroradiology, neuropathology, clinical research methods, epidemiology, biomarkers, policy, and global public health.

A similar approach has been used to generate a multisocietal universal definition of myocardial infarction (MI).

As knowledge, personnel, and technology evolve, we continue to learn about the nature, causes, and clinical and imaging findings in patients with cerebrovascular diseases.

The current World Health Organization definition of stroke (introduced in 1970 and still used) is “rapidly developing clinical signs of focal (or global) disturbance of cerebral function, lasting more than 24 hours or leading to death, with no apparent cause other than that of vascular origin.” During the 40 years since this definition was formulated, advances have been made in knowledge about the nature, timing, clinical recognition of stroke and its mimics, and imaging findings that require an updated definition.

The ability to safely and quickly image the brain and its blood-supplying vessels in patients has become a reality during the past 25 years.

And, in the past 10 years, modern brain and vascular imaging has become generally available in community medical centers, although many still today do not have this capability.

The updated definition of stroke incorporates clinical and tissue criteria and can be incorporated into practice, research, and assessments of the public health.